Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add filters








Language
Year range
1.
Braz. j. pharm. sci ; 45(4): 743-749, Oct.-Dec. 2009. ilus, tab
Article in English | LILACS | ID: lil-543671

ABSTRACT

The influence of caffeine, administered to rats, on the somatic and sensory-motor development of the offspring was investigated. Female Wistar rats were divided into a control group and a treated group and received drinking water and a 0.1 percent solution of caffeine orally, respectively. The offspring, also divided into a control group and a treated group, received daily monitoring until the 20th day of life to verify alterations in somatic neural development. The offspring of the treated group had reduced weight on the day of birth and on the 1st, 5th, 15th and 20th days of life; shorter snout-anus length (evaluation done daily); shorter snout-tail length on the day of birth and on the 1st, 5th and 10th days of life, and signs of retardation of somatic and sensory-motor maturation. These results allowed the conclusion that administration of caffeine to rats affects somatic and sensory-motor development of offspring.


Estudou-se a influência da cafeína, administrada a ratos, no desenvolvimento somático e sensorial-motor da prole. Ratos Wistar fêmeas foram divididos em grupo controle e grupo tratado e receberam água e solução de cafeína a 0,1 por cento, respectivamente. A prole, também dividida em grupo controle e grupo tratado, foi monitorada diariamente até o 20º. dia de vida para se observar as alterações no desenvolvimento somático neural. O grupo tratado apresentou peso reduzido no dia do nascimento e nos 1º, 5º., 15º e 20º. dias de vida; comprimento focinho-ânus mais curto (avaliação efetuada diariamente); comprimento focinho-cauda mais curto no dia do nascimento e nos 1º, 5º., 15º e 20º. dias de vida e sinais de retardamento da maturação somática e sensorial-motora. Esses resultados permitem que se conclua que a administração da cafeína a ratos afeta o desenvolvimento somático e sensorial-motor da prole.


Subject(s)
Animals , Male , Female , Adult , Rats , Caffeine/analysis , Caffeine/adverse effects , Caffeine/genetics , Muscle Development , Sensation , Somatoform Disorders/chemically induced , Maternal Exposure , Prenatal Exposure Delayed Effects , Central Nervous System
SELECTION OF CITATIONS
SEARCH DETAIL